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SOD1-Derlin-1 inhibitor 56-59

CAS No. 2170170-27-9

SOD1-Derlin-1 inhibitor 56-59( —— )

Catalog No. M35329 CAS No. 2170170-27-9

SOD1-Derlin-1 inhibitor 56-59 is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor 56-59 is potential in Amyotrophic lateral sclerosis (ALS) research.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SOD1-Derlin-1 inhibitor 56-59
  • Note
    Research use only, not for human use.
  • Brief Description
    SOD1-Derlin-1 inhibitor 56-59 is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor 56-59 is potential in Amyotrophic lateral sclerosis (ALS) research.
  • Description
    SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS).
  • In Vitro
    ——
  • In Vivo
    Animal Model:ALS model C57BL/6 mice Dosage:3?mM, flow rate 0.15?μL/h Administration:intracerebroventrical injection Result:Had significantly delayed onset, by a median of 4.5 weeks (14.5% improvement) and prolonged survival, by a median of 5 weeks (14.2% improvement).
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2170170-27-9
  • Formula Weight
    386.47
  • Molecular Formula
    C22H18N4OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (129.38 mM; Ultrasonic (<60°C)
  • SMILES
    Nc1c(sc2nc(ccc12)-c1cccnc1)C(=O)N(CC=C)c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668.?
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